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Showing posts with label Chemotherapy. Show all posts
Showing posts with label Chemotherapy. Show all posts

Saturday, May 30, 2015

Donie's news Ireland daily BLOG

Irish fuel prices increase for fourth month in a row?

    
Motorists in Ireland are paying more money to fill up their cars this summer as the price of fuel increases for the fourth month in a row.
The average price of a litre of petrol now costs 143.6c, 4.6c more than in April.
The average price of a litre of diesel has also risen – consumers are currently paying 133.1c per litre, 2.6c more than last month.
The increases were recorded by the AA’s national fuel price survey. According to the new figures, a motorist putting 30 litres of petrol in their car each week will now pay €43.08, which is €1.38 a week more than only a month ago.
Someone putting 30 litres of diesel in their vehicle each week will pay 78c more.
But despite the hike, fuel prices are still lower than they were this time last year. Last summer the average price of a litre of petrol was 154.3c, while a litre of diesel was 146.8c.
“Prices fell in the second half of last year but have been rising since February,” said Conor Faughan from the AA. “It was only a short reprieve. The recent rise looks set to continue with the weakening Euro making it even worse. It will be an expensive summer on the roads.”
Mr Faughan said the main reason for the country’s high fuel prices is due to the Government’s tax, including an extra 23c per litre in austerity-era tax increases added since 2008. “When you spend €1.48 on a litre of petrol, 92c of it is tax. A tax-free litre, even with recent price rises, only costs 51.8c.”
Meanwhile, the European Consumer Centre (ECC) advises people thinking of buying a car to be wary of scams.
“Car purchase scams remain a persistent problem for consumers. In 2014, such scams accounted for 14% of all car purchase queries to ECC Ireland,” it said and cautioned against paying any money by bank transfer or to an escrow or delivery service.
“Fraudsters may ask consumers to send payment by bank transfer or via money wiring services, only for the seller and vehicle to disappear once the money is sent. This is particularly commonplace in internet transactions. Consumers may also be asked to send payment to an intermediary, such as an escrow company, who will then deliver the car to them. Consumers are often told that they will not have to pay if they are not happy with the vehicle. Unfortunately, in many cases, the intermediary disappears once the money has been sent.”
Consumers who fall victim to a scam are urged report it to Gardaí as soon as possible.

Price of posting in Ireland set to increase shortly (Std. letter 68c to 70c)

   

Postage rates are to increase on July 1, An Post has announced.

The standard domestic letter rate for items up to 100g within Ireland will increase from 68c to 70c while the standard international letter rate up to 100g will increase from €1 to €1.05.
“Despite the increase, An Post’s rates will remain among the lowest in the EU 15 countries including Britain, Germany, Belgium and the Netherlands and well below the EU domestic average of 77c,” said a statement from An Post.
“A wide range of discount options continue to be available to businesses.
“The existing Meter rate for Standard Post letters will remain unchanged at €0.66 per item and a wide range of significant discount options continue for Ceadúnas licence and bulk-mail services.”
The company defended the increase, saying that it is necessary “to stem the unsustainable financial losses arising from the company’s Universal Service Obligation.
“Losses totalled €38m in 2014 – whereby customers in all areas of the country are provided with daily collection and delivery services for a uniform tariff.
“An Post continues to offer excellent value for money to Irish businesses of all sizes and to personal customers.”

Thumbs up for EU-US trade from Irish public in nationwide poll

   
More than three quarters (77%) of Irish people in a nationwide poll hold the view that Ireland should stay in the EU, even if the UK leaves it.
The poll was conducted following the newly elected UK government’s promise in the Queen’s speech at the opening of the new UK parliament to hold an ‘in/out’ referendum on the country’s membership of the union.
According to the Red C poll commissioned by independent, not-for profit organisation, European Movement Ireland, 86% of respondents believe Ireland should remain part of the EU, with 84% of adults here believing that Ireland has, on balance, benefitted from membership of the EU.
These figures are higher than those in a similar poll carried out in 2013.
In addition, around seven in 10 Irish adults support the Transatlantic Trade and Investment Partnership between the EU and US.
The poll was conducted among a representative sample of over 1,000 people aged 18 and over from across the country.

How green tea could cut prostate cancer development in men

  

In a new study, scientists have revealed that a component found in green tea may help reduce development of prostate cancer in men facing high risk.
In a new study, scientists have revealed that a component found in green tea may help reduce development of prostate cancer in men facing high risk.
A team of researchers led by Nagi B. Kumar, Ph.D., R.D., F.A.D.A. at Moffitt Cancer Center assessed the safety and effectiveness of the active components in green tea called, “catechins” to prevent prostate cancer development in men who have premalignant lesions.
20 percent of green tea is consumed in Asian countries where prostate cancer death rates are among the lowest in the world and the risk of prostate cancer appears to be increased among Asian men who abandon their original dietary habits upon migrating to the U.S.
Laboratory studies have shown catechins inhibit cancer cell growth, motility and invasion, and stimulate cancer cell death. Green tea catechins also prevent and reduce tumor growth in animal models. Epigallocatechin-3-gallate (EGCG) is the most abundant and potent catechin found in green tea responsible for these cancer prevention effects.

Shock rise in health insurance premiums for Irish people insured for 1st time  

  

One of the plans going up is the €425-a-year Starter Select, an entry-level plan introduced to capture new entrants ahead of the lifetime community rating changes

Health insurance premiums are to rise at Aviva – just weeks after thousands of people took out cover for the first time.
The insurer is to implement rises averaging 5.5% on 106 plans for those renewing or taking out cover from July, in a move that will see some policies costing between €200 and €470 more for families.
The rises come just weeks after an extra 74,000 people took out health insurance ahead of the introduction of late-entry penalties as part of lifetime community rating.
One of the plans going up is the €425-a-year Starter Select, an entry-level plan introduced to capture new entrants ahead of the lifetime community rating changes.
Aviva had already increased premiums in January.
Experts had been expecting few, if any, rises this year. This view was reinforced when both VHI and Laya cut the cost of a number of plans and froze premium ratings on others.

New immunotherapy drug outperforms chemotherapy for a form of lung cancer

    

Philip Prichard, of Memphis, has seen his renal cell cancer virtually wiped out by the immunotherapy drug nivolumab.

A new drug that unleashes the body’s immune system on cancer cells performed better than a traditional chemotherapy agent in fighting an advanced form of lung cancer, researchers reported Friday. The new drug was also less toxic to patients.
Nivolumab, one of three government-approved drugs that stimulate the immune system to take on foreign invaders, improved outcomes for 19.2% of patients with non-squamous cell non-small cell lung cancer, compared with 12.4% of people who were treated with docetaxel. Patients also survived longer — a median of 12.2 months vs. 9.4 months for those on chemotherapy, and saw a 27% smaller chance of death while on the drug.
Patients whose tumors released a specific kind of protein did even better in the study of 582 people, surviving 17.2 months, vs. 5.6 months for the chemotherapy group.
“There is no doubt that immunotherapy has come to stay in lung cancer,” said Luis Paz-Ares of the Hospital Universitario Virgen Del Rocio in Sevilla, Spain, who led the research.
Immunotherapy works by removing the brakes or “checkpoints” that keep killer T-cells from recognizing and attacking cancer. In the past few years, it has quickly become the fourth, and perhaps most promising, avenue of cancer treatment, alongside surgery, radiation and chemotherapy.
[He had months to live before immunotherapy made his tumors disappear.]
Lung cancer is the leading cause of cancer deaths world-wide and 1.8 million people will be diagnosed with it this year, Paz-Ares said. The Food and Drug Administration approved nivolumab earlier this year for use against squamous cell non-small cell lung cancer, but this group of people is considerably larger. Paz-Ares said he expects FDA approval to use the drug on these patients soon.
Two other immunotherapy drugs are government-approved for treatment of melanoma, a lethal form of skin cancer, as is nivolumab.
Only 7 percent of the nivolumab patients suffered side effects from the medication, a smaller proportion than the 20 percent who took docetaxel. And they suffered a much smaller number of serious side effects.
The new research was presented at the annual meeting of the American Society of Clinical Oncology, where 35,000 people in the field are gathered.
In a second study presented Friday, researchers from Johns Hopkins University and elsewhere showed that genetic testing can be used to predict whether the cancers in a small percentage of people will respond to immunotherapy. The test could be valuable in determining how to use the highly expensive checkpoint inhibitor drugs, which can cost $10,000 a dose or more.
Many of the cancers examined in the study had been considered poorly responsive to immunotherapy. They included colorectal, endometrial, stomach and small bowel cancers.
But the team led by Dung T. Le, a medical oncologist at the school’s Kimmel Cancer Center, showed that tumors with genetic defects that make them poor at repairing errors as DNA is synthesized mutate hundreds and perhaps thousands of times. Those mutations express a protein that can tell doctors whether the tumor will be a good candidate for immunotherapy.
Le said at a media briefing that her study is the first “to use genetics to guide immunotherapy.” The small, early stage study involved 41 patients who were treated with pembrolizumab, one of the drugs the FDA has approved for treatment of melanoma.
Overall, Le said, the “mismatch repair deficiency” used to guide the therapy is present in just 4 to 5% of many cancer types. But in some, it may be found in as many as 40% of tumors. The tests cost just a few hundred dollars and in some cases may be conducted anyway, so they would not add extra costs to a patient’s care, she said.

Great Barrier Reef Is Not ‘in Danger’ but Needs Care,

U.N. Experts Say

    
Despite threats to the Great Barrier Reef from climate change and human activity, United Nations conservation experts stopped short of recommending on Friday that the reef, a World Heritage site, be classified as “in danger.”
Even so, the overall outlook for the reef remains poor, and Australiashould improve its management of it, the World Heritage Center and the International Union for Conservation of Nature said in their report. The document cited climate change, water pollution and the impact of coastal development as major threats.
In particular, scientists and conservationists have sharply criticized plans to expand the Abbot Point coal-loading port in Queensland, which would involve the dumping of dredge spoils in waters near the reef, which includes 1,050 islands and stretches along almost the entire eastern coast of Queensland.
The experts’ recommendation, published in Paris, now goes to a vote by the World Heritage Committee, which includes representatives of 21 countries and is scheduled to meet next month in Bonn, Germany.
Greg Hunt, the Australian environment minister, said on Friday that the government was committed to a 35-year plan to restore the reef to good health, a fact noted in the recommendation.
“We have listened intently and responded directly to the concerns from the Australian community, the World Heritage Committee and their technical advisers,” Mr. Hunt said in a statement. He said the national government and the state of Queensland should invest about $1.5 billion in the reef over the next decade.
But conservationists have criticized the government of Prime Minister Tony Abbott for supporting the expansion of the port and the Galilee Basin coal mines that use it.
Under pressure from environmentalists, Mr. Hunt has said the government will permanently ban the dumping of dredge spoils from new port projects in the Great Barrier Reef Marine Park. But the ban would not cover dredging to maintain the depth of existing shipping channels and ports, which could still dump more than a million tons of sludge a year in reef waters, according to Jon C. Day, who was a director at the Great Barrier Reef Marine Park Authority from 1998 to 2014.
WWF-Australia, an environmental advocacy group, said in a statement that the United Nations was placing Australia on probation. “The draft decision acknowledges progress, but keeps the pressure on the Australian government to turn their commitments into real actions and results, or find themselves having to explain to the World Heritage Committee in 2017 why they’ve failed to meet their commitments,” the statement said. The group said the government had not allocated enough money to the reef protection plan.  

Saturday, March 21, 2015

Donie's Ireland daily news BLOG update

A Polish/Irish festival celebrates our special 10 year relationship

A week long eVENT HONOUR'S THE 150,000 MEMBERS OF THE POLISH COMMUNITY IN IRELAND

 
Hannah Barwinska, Natalia Gil and Veronika Blaszczak (all age 11 from Polish School SEN) participate in the Brighter Futures pageant during the St Patrick’s Day parade in Dublin last Tuesday the 17th March 2015.
June 18th, 2012, and Market Square in Poznan, Poland, (above right) is thronged. It’s the last chapter in what has been a whirlwind summer romance between the Poles and the Irish. Irish football fans have endured a nightmare of a week in terms of results at Euro 2012, but none of them will forget the friendship that blossomed between them and their Polish hosts.
After eight days of heavy defeats, the Irish are nursing sore heads and bruised egos. A band of Poles have organised a gathering to “say goodbye to Ireland in our way”.
As the gathering begins, there are ripples in the crowd when the Poles begin to sing, not their native songs, but rousing renditions of The Fields of Athenry and other verses the Irish have been singing all week. They have learned the music and the words. The depth of the gesture is lost on nobody.
Flyers are distributed in the square. “We remember your great sportsmanship during your football game with Spain in Gdansk,” they say. “We remember your inspiring song The Fields of Athenry that brings into memory some of your history no one should ever forget. We too have a very hard past. We are also romantic and emotional people. This is something our nations have in common.”
The love affair between the Polish and the Irish may have been consummated here but this is not where it all began.Tens of thousands of Poles have migrated to Ireland since the State opened its borders to an enlarged EU in 2004.
Along the way there have been “misunderstandings” that have become folk tales. At one stage a Polish man seemed to be establishing himself as Ireland’s most reckless serial road traffic offender. By June 2007, Prawo Jazdy had more than 50 separate entries under his name in the Garda Pulse computer system, but with different addresses and not a single conviction. In the end the clue to his identity lay within the pages of a Polish-English dictionary. “Prawo jazdy” means driving licence. Garda officers were mistaking it for the driver’s name.
Every part of the country has a Polish presence that has added to community life. Few Irish towns have been left without a Polski sklep that sells pickles, Polish beer or smoked fish.
Of course, the pollution of the Irish gene pool has been perhaps the greatest development.
The contamination of the scraggly, pasty-skinned ginger archetype of the Irish has long been a matter of great urgency – and who better than the stunning Poles to do just that.
There are now Jakubs married to Aoifes and Seáns to Magdalenas.
It’s just a wonder there hasn’t been a Polish-Irish festival before now. The first one begins today, a week-long event aiming to celebrate the 150,000 members of the Polish community living in Ireland.

Ireland makes an early IMF repayment 

“leaving only 20% more to clear debt”

  

Ireland has made the last of its early loan repayments to the International Monetary Fund, leaving the country with just under a fifth of the original €22.5bn bailout left to pay.

  Friday’s payment was supposed to be due between July 2015 and January 2021 but with an average interest rate of 4.99%, Ireland’s bailout funds were far more expensive than the country’s borrowing rate on international markets, encouraging the government to pay the debts down as soon as possible, writes Elaine Moore in London.
Government borrowing costs across Europe have plummeted following the European Central Bank’s decision to begin a large scale programme of bond buying to boost the region’s economic recovery.
Last year Ireland’s benchmark borrowing rate dropped below the UK’s for the first time in six years highlighting the speed with which the country’s economy has turned around since the Eurozone debt crisis.

Oncotype DX test means no chemotherapy for some breast cancer patients

The gene test is only available here since 2011.

    

A study on a new test for breast cancer shows that it reduces the need for chemotherapy in some patients.

The test, Oncotype DX, involves a sample of the tumour being taken and sent to the US for gene testing. It has only been available in Ireland for four years.
Suitable patients?
Patients who are suitable for the test and whose cancer is node negative and hormone positive can have their tumour gene-tested.
The test looks at the activity of 21 genes in this particular breast cancer, and is able to see how the cancer is going to behave into the future and whether it would benefit from chemotherapy or not.
Genomic Health presented 11 studies today in Vienna, Austria, on the test in Ireland.
A study
They include a real-life observational study in Ireland, which demonstrates significant reductions in chemotherapy and cost savings when the test is used in early-stage breast cancer.
Dr Janice Walsh, Consultant Medical Oncologist at St Vincent’s University Hospital in Dublin, led the research project for the All Ireland Co-Operative Oncology Research Group (ICORG) in collaboration with the National Cancer Control Programme (NCCP).
Dr Walsh told TheJournal.ie that the test has been standard practice in the United States since 2005, but was only introduced in Ireland, following a long campaign, in 2011.
Ireland was the first European market to publicly reimburse the test.
The study at Irish hospitals showed that out of the 583 patients who were included in the analysis, 59% underwent a change in their treatment decision.
339 of the patients would have been recommended chemotherapy had they not undergone the test – the test showed that they could be changed to hormone therapy alone, as chemotherapy would have given them minimal or no benefit.
Dr Walsh said this is “hugely significant” as it means the patients can avoid the side effects from chemotherapy.
It is estimated that there are about 600 eligible patients a year.
Breast cancer is the most frequently diagnosed cancer in Irish women.
Kieran Kenny of Genomic Health said that the test has demonstrated value for patients and the health care system.

Experimental Oncotype DX test

 by Biogen offers hope to scientists

That they may be closer to a breakthrough

The shares in Biogen jump 7% in New York trading

    

The Biogen’s market value share has risen by $45 billion to nearly $110 billion in a little over a year

An experimental Alzheimer’s drug being developed by a US biotech group has offered hope that scientists may be closer to a breakthrough for the devastating disease, after early trials showed the treatment slowed the rate of cognitive decline.
Biogen’s Aducanumab is one of several drugs under development by big pharmaceutical groups that aim to reduce so-called “amyloid plaque”, a sticky build-up in the brain that many believe is responsible for Alzheimer’s disease.
A year-long study of 166 patients with a mild form of the disease showed that Biogen’s drug significantly reduced the build-up of plaque and delayed the onset of cognitive decline, according to data published yesterday at a medical conference in Nice, France.
Shares in Biogen, which have risen about 28% this year in anticipation of the data, jumped by 7% in New York trading, while other companies with similar drugs also gained, including Eli Lilly, up 2.4%, and Sanofi, which added 1.6%.
Biogen’s market value has risen by $45 billion to nearly $110 billion in a little over a year.
However, analysts and doctors voiced concerns over the drug’s safety, with a quarter of patients on the highest dose discontinuing treatment due to adverse effects, including swelling on the brain. Drug companies have trialled similar drugs for years with disappointing results, but the industry has pressed ahead because the commercial opportunity is huge: there are more than 25 million Alzheimer’s sufferers globally and five million in the US, the majority of whom do not respond to existing treatments.
Biogen and its partner Neurimmune developed the drug by cloning the memory cells of people in their 90s who had “super cognitive function” despite their age, as well as people who had Alzheimer’s that was progressing at an unusually slow rate.

Speed limit’s likely to be cut to many of rural Ireland road networks

  

Transport Minister Paschal Donohoe yesterday predicted “many” rural roads are likely to see their maximum speed limit cut from 100km/h to 80km/h under new guidelines.

The guidelines also call on local authorities to “give serious consideration” to reducing speed limits from 50km/h to 30km/h within housing estates, where houses are fronting the roads, and near play areas.
Mr Donohoe said he continued to believe “very strongly” that local authorities must retain the power to determine speeds in housing estates — despite calls for a mandatory 20km/h speed limit by Roseann Brennan, whose six-year-old son, Jake, died after being knocked down by a car near his home in Lintown Grove, Kilkenny, last June.
The minister said the lowest speed local authorities can introduce under the law was 30km/h, but new legislation he was bringing through the Oireachtas would allow councils to have a 20km/h speed limit.
Mr Donohoe was speaking at the launch of Guidelines for Setting and Managing Speed Limits.
Under the document:
National roads less than 7 metres in width and more than 3km in length should have a maximum limit of 80km/h — while those over should be 100km/h zones.
A new road sign — a white circle with black diagonal stripes — will replace the 80km/h sign on narrow country roads, but the maximum speed will remain unchanged.
Urban speed zones will be determined by their function (arterial, link or local road) and their context (commercial or housing areas).
Mr Donohoe said a website, http://www.speedlimits.ie, would go live in the coming weeks, with a map giving limits on all roads.
Asked whether he expected a significant reclassification of areas from 50km/h to 30km/h, Mr Kelly said he thought there would be “more change” regarding rural roads, where limits would be determined by new criteria — regarding their width and length.
“You are likely to see a reclassification from 100km/h to 80km/h on many of these,” he said.
He also revealed new signage on country roads that legally have 80km/h speed limits, but where drivers need to exercise caution.
“This new generic sign is in use internationally,” said the minister.
“This sign means that drivers must use their judgement when using the road in question but must not exceed 80km/h.”
The signs are expected to be erected in April.
Moyagh Murdoch, RSA chief executive, said 80km/h country roads with “grass growing up the middle and clearly incapable of taking two cars had brought the system into disrepute”.
She said they would be running online, mobile and print media advertising campaigns backing the changes.
Mr Donohoe said Roseann Brennan had made “a very important contribution” in raising the profile of speed in residential areas. However, he said 20km/h was “just over 12 miles an hour” and the “level of motion has to be credible”. He thought 30km/h was “credible” and this was shown by international best practice.

Why is that mushroom glowing in the dark?

  

Many species of mushrooms glow in the dark. This bioluminescence is being studied by scientists to determine its function.

If you think you see a glowing mushroom, you might not be having a psychedelic hallucination. Some mushrooms indeed are bioluminescent, including one that sprouts among decaying leaves at the base of young palm trees in Brazilian coconut forests.
Scientists have long wondered what possible reason there could be for a fungus to glow. They now have an answer.
Researchers say that experiments in Brazil involving the big, yellow mushroom called “flor de coco,” meaning coconut flower, showed its night time bioluminescence attracted insects and other creatures that could later spread its spores around the forest.
  1. gardneri mushrooms growing on the base of a young babassu palm in Gilbues, Brazil. Photo: REUTERS/Michele P. Verderane
“Our research provides an answer to the question, ‘Why do fungi make light?’ that was first asked, at least first asked in print, by Aristotle more than 2,000 years ago,” says biochemist Cassius Stevani of Brazil’s Instituto de Química-Universidade de São Paulo.
“The answer appears to be that fungi make light so they are noticed by insects who can help the fungus colonize new habitats.”
Geneticist and molecular biologist Jay Dunlap of Dartmouth College’s Geisel School of Medicine says bioluminescence had independently evolved many times in such diverse life forms as bacteria, fungi, insects and fish.
“Most of these make light in their own way, that is, with biochemistry that is unique to each organism,” Dunlap says.
Of the 100,000 known fungus species, 71 are bioluminescent. The species in the study, published in the journal Current Biology, is one of the biggest and brightest of them.
The researchers found a circadian clock regulates its bioluminescence, glowing only at night.
They created two sets of plastic mushroom replicas, one with LED lights replicating bioluminescence and a second set with no light. Suspecting the glow might be used to entice insects, they put glue on both sets of phoney mushrooms in forest locations where real ones grow, then tracked the beasties that got stuck.
The glowing replicas lured an array of ants, cockroaches, flies, beetles, spiders, harvestmen, slugs, snails and centipedes.
Such creatures, after crawling on a real bioluminescent mushroom, disperse fungal spores around the forest.
Dunlap speculated that many of Earth’s bioluminescent mushrooms likely developed their glow for that purpose.
“Because it has evolved so many times in so many different organisms, each with their own biology, studying bioluminescence gives one a window on living things in all their wonderful diversity, and it sends you off to questions that you did not know existed,