Pages

Showing posts with label mental health in Ireland. Show all posts
Showing posts with label mental health in Ireland. Show all posts

Tuesday, October 16, 2012

Donie's news Ireland daily BLOG


Price cuts on medicines will reduce the Irish State bill by €400m

€400m

The cost of hundreds of commonly used medicines will drop by an average of 10 per cent as a result of the agreement reached by the Department of Health and the manufacturers of branded pharmaceuticals.

The deal will knock €400 million off the State’s drugs bill over the next three years, according to both Minister for Health James Reilly and the Irish Pharmaceutical Healthcare Association, which represents the makers of branded medicines.
It will also result in lower prices for consumers buying their medicines over the counter, so long as savings in wholesale prices are passed on by pharmacists.
The projected overall reduction equates to about 7 per cent of the State’s €1.9 billion annual spend on drugs, but sources close to the talks said the average price drop would be somewhat higher than this.
No details of the price reductions that will apply to individual drugs were available yesterday, but the HSE is expected to publish details of the reduced prices that will apply from next month on its website by the end of the week.
In return for making price concessions, the pharmaceutical companies won acceptance of the principle that new medicines will be approved under the HSE’s drug schemes once they have been proven to be cost effective.
This could result in substantial future costs for the health service, as some of the sophisticated new treatments being developed by drug companies are hugely expensive.
The HSE is spending an additional €30 million this year on providing just six new cancer, hepatitis C and anti-coagulant drugs.
The agreement will not affect the price of most generic drugs, but this is being tackled through talks with the manufacturers of these drugs and proposed new legislation.
Under the legislation which comes before the Dáil today, a pharmacist will be able to dispense a generic version of a medicine even when a specific brand has been prescribed.
If a patient wants a more expensive branded drug, they will have to pay the difference in price.
The agreement with the drug companies is welcome relief for Dr Reilly, who has been embroiled in controversy for the past month over the siting of primary care centres in his constituency.
A clearly pleased Minister described the new deal yesterday as a “good news story” for all patients and not just those suffering from serious illnesses.
“It’s a good news story for patients because patients who have to buy their medicines across the counter will find it more affordable now, it will be cheaper. And for those who have medical cards, it means that the money that had been going into producing the drugs they require will now be available for other services within the GMS,” he said.
Speaking during a visit to Limerick yesterday he admitted it had been difficult to bring about the deal, which he said “took a long time”.
Proposals to cut the cost of medicines were the subject of intensive lobbying of the Government by the pharmaceutical multinationals, which account for half of Irish exports and employ 25,000 people.
However, the Government was also coming under increasing pressure from the troika over the escalating deficit in the health service.
Under the agreement, the biggest price falls of up to 50 per cent will apply to drugs that are already off patent or are going off patent.
However, this represents a minority of these companies’ business as the IPHA represents research-based companies that derive most of their profits from new drugs still on patent. Some 400 of these patent protected drugs will be the subject of a price review, according to the terms of the agreement.
Average reductions of up to 16 per cent are promised from this process.
A taskforce on prescribing and dispensing is also to be set up with the aim of delivering further cost saving by encouraging “more cost conscious prescribing”.
The cost of medicines to the Irish consumers is among the highest in the world. One recent survey found that the Irish prices for patented drugs were 45 per cent higher than in Sweden.
Meanwhile, the makers of generic drugs can charge up to 95 per cent of the cost of the branded equivalent.

Irish seaweed (dulse) could prove a boon in battle against high blood pressure

     

A common Irish seaweed could be used to reduce blood pressure, according to findings by Teagasc food scientists.

Members of the NutraMara marine research group, the scientists in Teagasc’s facility at Ashtown, Co Dublin, have found a renin-inhibitory peptide in the seaweed palmaria palmata, commonly known as dulse, a significant find as renin-inhibitory peptides have not been found in seaweed species before.
Commonly featured in pharmaceutical drugs, renin inhibitors are bioactive agents which are used primarily in the treatment of hypertension.
The Teagasc research could eventually have applications for foods and pharma companies.
Cardiovascular disease accounts for more than 4.3m deaths globally each year and high blood pressure is a main cause of the disease. Used as a protein source, the researchers have found that some seaweed proteins may have health benefits for use in functional foods.
The peptides are currently being assessed in bread products. Research work at Teagasc will also assess the effects of the seaweed protein hydrolysates on the technical and sensory attributes of bakery products, in particular bread.
Teagasc researcher Maria Hayes said: “Currently, analysis of a P palmata bread product is under way and the effects of the hydrolysate on the moisture content, ash, crude fat, fibre, and protein content have been assessed. The effects of the seaweed protein on the colour and texture profile of the bread are also being carried out.”
Teagasc researchers are looking to seaweed for proteins with health benefits for use as functional foods. Historically, seaweeds were consumed by coastal communities worldwide. Seaweed is a habitual diet in many countries, particularly in Asia.
Whole seaweeds have been successfully added to foods in recent times, ranging from sausages and cheese to pizza bases and frozen-meat products.
NutraMara programme manager Fiona Manning said: “NutraMara is trying to find bioactive components for use in functional foods. We are funded by the Marine Institute and we are looking specifically at marine sources; for example, how fish discards and waste streams can be used to have a positive effect in functional foods.”
The researchers have also shown that protein-rich red seaweeds such as dulse and porphyra (common name sleabhac or laver) species may potentially be used in the development of low-cost, highly nutritive diets that may compete with current protein crop sources such as soya beans.
For example, the protein content of dulse varies from between 9% and 25% depending on the season of harvesting.
The highest ratio of protein per gram in dried whole seaweed is normally found in dulse collected from October to January.
Dulse contains valuable amino acids such as leucine, valine, and methionine. In porphyra species, the amino acid profile is similar to those of peas or beans.
Bioactive peptides are food-derived peptides that exert a physiological, ‘hormone-like’, beneficial health effect. Proteins and peptides from food sources such as dairy, eggs, meat and fish are agents capable of reducing high blood pressure and are thought to be able to prevent cardiovascular disease.

‘Healthy advice’ now 7 portions of Fruit & Veg a day is a must for mental health well-being

  
If you do one thing this week . . . aim for seven portions of fruit and vegetables day.

“Make sure you get your five a day” – it’s common and sound advice to include plenty of different fruit and vegetables in our daily fare.

But should we be aiming for higher numbers?
A new study at Warwick University in the UK and Dartmouth College looked at cross-sectional data from around 80,000 people in England, Scotland and Wales.
And the analysis found that mental wellbeing peaked not at five but at seven servings of fruit and veg a day, where a serving is around 80 grams.
It’s important to stress that the study, due to be published in Social Research Indicators, doesn’t establish a causal link. But maybe it’s another motivator to reach for the fruit bowl instead of the biscuit barrel and to heap the dinner plate with an array of vegetables.

“Fearless Felix” the Skydiver breaks the sound barrier in 9 minutes

  
Felix Baumgartner jumps from more than 24 miles up on his way to shattering the sound barrier
In a giant leap from more than 24 miles up, a daredevil skydiver shattered the sound barrier on Sunday while making the highest jump ever – a tumbling, death-defying plunge from a balloon to a safe landing in the New Mexico desert.
Felix Baumgartner hit Mach 1.24, or 833.9 mph, according to preliminary data, and became the first person to reach supersonic speed without travelling in a jet or a spacecraft after hopping out of a capsule that had reached an altitude of 128,100 feet above the Earth.
Landing on his feet in the desert, the man known as “Fearless Felix” lifted his arms in victory to the cheers of jubilant friends and spectators who closely followed his descent in a live television feed at the command center
“When I was standing there on top of the world, you become so humble, you do not think about breaking records anymore, you do not think about gaining scientific data,” he said after the jump. “The only thing you want is to come back alive.”
A worldwide audience watched live on the Internet via cameras mounted on his capsule as Baumgartner, wearing a pressurised suit, stood in the doorway of his pod, gave a thumbs-up and leapt into the stratosphere.
“Sometimes we have to get really high to see how small we are,” an exuberant Baumgartner told reporters outside mission control after the jump.
  Baumgartner’s descent lasted just over nine minutes, about half of it in a free fall of 119,846 feet, according to Brian Utley, a jump observer from the FAI, an international group that works to determine and maintain the integrity of aviation records. He said the speed calculations were preliminary figures.
Baumgartner said travelling faster than sound is “hard to describe because you don’t feel it.” The pressurized suit prevented him from feeling the rushing air or even the loud noise he made when breaking the sound barrier.
With no reference points, “you don’t know how fast you travel,” he said.
The 43-year-old former Austrian paratrooper with more than 2,500 jumps behind him had taken off early Sunday in a capsule carried by a 55-storey ultra-thin helium balloon.

Galway bay organic salmon fish farm could create 500 jobs

 

A PUBLIC consultation has begun into Bord Iascaigh Mhara’s licence application process for a deep-sea fish farm in Galway Bay near the Aran Islands.

The project has been described by BIM’s chief executive Jason Whooley as “extremely significant” involving a potential 500 jobs and €100 million of exports.
The licence application is for the production of 15,000 tonnes of organic-certified salmon a year which would double Ireland’s current salmon production.
Mr Whooley said this output would be built up over six years. The 500 new jobs would involve 350 jobs in production and processing and 150 indirectly in areas such as transportation and materials.
Mr Whooley said this would provide a €14.5 million annual wages flow, mainly in the vicinity of the proposed farm. Rossaveal is the nearest landing point for the fish.
Irish organic-farmed salmon is a premium product in Europe, and commands on average a 50 per cent premium on farmed salmon produced elsewhere. “The single biggest issue facing Irish salmon producers today is that they cannot fulfil the demand for their product,” said Mr Whooley.
The licence application must be approved by Minister for Agriculture, Marine and Natural Resources Simon Coveney, and over the next eight weeks any member of the public may make submissions to his department.
Friends of the Irish Environment has expressed concern at the fact that the department which approves the licence is also overseeing the body that has made the application.
Its director, Tony Lowes, said this was “regulatory capture at its purest”.
He has also raised concerns about issues such as the scale of the project, the potential for pollution and the spreading of disease.
Mr Whooley said an unprecedented level of scientific research had gone into identifying the locations, with some of the State’s most eminent marine scientists involved.
“We are confident that the very carefully chosen locations, matched with the rigorous monitoring that must accompany any salmon farm in Ireland, will enable the proposed development to run successfully and produce premium organic salmon, something that Ireland is world renowned for.”
He said the agency was committed to full and transparent communications during this consultation process, and wanted to ensure that members of the public were fully informed about the proposed development.
All of the application information, including the environmental impact statement, drawings and artists impressions of the proposed development, are now available on the BIM website bim.ie.
Copies have also been left in places such as Garda stations and post offices in the immediate area, and information meetings will be held over the coming weeks.
If the project is approved BIM will seek a suitable commercial operator to run the salmon farm. However, it will retain the licence so that the natural resource remains in the ownership of the State.
“This approach will allow BIM to apply additional standards to the running of the farm, to maximise returns to the local coastal economy in accordance with our mission to develop the Irish seafood industry and sustain coastal communities,” Mr Whooley said.

Barclays Entrepreneurs Index shows Irish firms making losses

   
A new report by Barclays assessing buying and selling of companies across Ireland and Britain has found that Ireland was the only country where on average businesses experienced a loss.
Barclays Entrepreneurs Index found over 440 growing Irish firms saw a change in shareholding between the second half of 2011 and first half of 2012.
The report is the first of its type to track shareholder changes in growing businesses with turnovers between €6m and €248m across Ireland and Britain.
The report, based on data from the Companies Registration Office, found that due to difficult trading conditions, the growing companies in Ireland that saw shareholder changes experienced an average loss of €550,000.
The report is based on the assumption that shareholder changes are caused by firms running out of funds due to shareholders selling stakes.
Ian Talbot, CEO of Chambers Ireland, said: “These findings are largely consistent with what we’re seeing on the ground.
“Certain sectors have been affected by the troubles in the construction industry, which has caused a slump in profits and had a knock-on effect on associated sectors and services. However, there are also opportunities in this climate for surviving companies in the market to acquire smaller businesses, which in turn, creates growth and employment.”
Ireland was the only region where the companies measured averaged a loss.
In the North, the average profit of the 132 firms measured was €1.7m. London returned the highest figure with an average profit of €4.27m from the 2,000 firms that have seen changes in shareholdings.
The Irish companies included in the study were also on average the youngest across England and Ireland. The average age of an Irish company was 15.5 years. The UK average was 20 years.
However 15 years is a sizeable period suggesting these companies were not being set up and sold on, or flipped, quickly.
Pat McCormack, head of wealth and investment management at Barclays Ireland said: “The overall decline in shareholder changes in these companies indicates that it is harder for businesses to be sold, mainly due to the continued uncertainty in the global economy.
“Acquirers are less willing to take risks, and the business owners themselves are more likely to sit it out until conditions improve.”

Monday, September 10, 2012

Donie's Ireland news BLOG Monday


ISME survey shows 49% refusal rate for Irish businesses bank credit

ISME Chief Executive Mark Fielding has described the survey results as “alarming”, and indicated the issue of bank credit remains a serious problem for the economy.    
The Irish Small and Medium Enterprise organisation claims that 49% of small and medium firms have been refused bank credit in the last three months.
It reveals a slight improvement on the 54% in the previous quarter.
Their Quarterly Bank Watch Survey, conducted in the week ending September 7, shows that demand for bank credit was steady at 38% in the same period.
The association has called on the Government “to immediately demand full and complete disclosure from the bailed out banks on lending to SMEs”.
They siad that the report backs up the recent report from the Central Bank “that access to bank finance is being denied to viable but vulnerable businesses”.
The survey attracted 862 responses.

Stigma still persists on mental health in Ireland

       

New figures have shown that lack of understanding of mental health problems is still fuelling stigma and preventing people from getting the support they need.

The findings from St Patrick’s Hospital in Dublin show that one-fifth of people surveyed believe that those suffering from mental health problems are of below average intelligence.
In addition, nearly one-in-three respondents said they would not willingly accept someone with a mental health problem as a close friend.
The findings were published to coincide with World Suicide Awareness Day.
The survey also found that nearly two-in-three people would discriminate against hiring someone with a history of mental illness on the grounds that they may be unreliable and 42% felt that undergoing treatment for a mental health problem is a sign of personal failure.
St Patrick’s Hospital CEO Paul Gilligan said the findings highlight the critical requirement to reduce stigma and barriers to accessing mental healthcare.
“It’s also essential that those looking for help are provided with adequate high quality services they can trust in.”
The survey was conducted among 300 members of the public.
The results show that exposure to mental health problems is very widespread, with 40% of respondents revealing that a close member of their family has been treated for a mental health issue.
Tom Maher, head of clinical servics at St Patrick’s, stressed that we need to prioritise the promotion of mental health literacy among the general population. The hospital is organising a free series of mental health information evenings for families and carers.
Meanwhile, the HSE is marking World Suicide Prevention Day by gathering together over 130 participants from various agencies and orgnisations at a conference in Dublin today to share evidence-based best practice on suicide prevention.
The HSE says the conference will discuss oppprtunities for better coordination of suicide prevention initaitives.
The meeting will highlight a research study carried out by the Headstrong organisation and UCD recently which shows that rates of suicidal thoughts and self-harm were higher in young adults who did not seek help or talk about their problems.
The HSE says early intervention programmes in GP practices and hsotpitals targeted at people at risk will help prevent suicides in Ireland.

Transgender legislation pledged by Irish Government soon

   
Joan Burton said legislation to provide for the legal recognition of transgender people is to come before a joint Oireachtas committee
Legislation to provide for the legal recognition of transgender people would be put before the Joint Oireachtas Committee on Social Protection in coming weeks, the Minister Joan Burton has said.
Speaking at the opening session of the fourth European Transgender Council meeting in Dublin today she said the enacting of such legislation was a priority for her, though she was unable to give reassurances on a number of key issues to trans people.
Transgender delegates from across Europe are in Dublin for the council meeting, which continues through the weekend and is hosted by the Transgender Equality Network Ireland (Teni).
It is 15 years since the Free Legal Advice Centres (Flac) issued legal proceedings to assert the right of transgender woman Lydia Foy to legal recognition of her gender. Though the High Court ruled against her in 2002 it ruled in her favour, in new proceedings, in 2007.
Michael Farrell, senior solicitor with Flac, who led Ms Laffoy’s case, said it was was “unacceptable” that Ireland remained the only country in Europe where there was no legal recognition of transgender people.
Legislating for recognition of transgender people was “not an option for the Irish Government”, given its acceptance in 2010 that it was in breach of the European Convention of Human Rights, he said.
“The jurisprudence of the European Court of Human Rights is clear and unambiguous. Trans people are legally entitled to recognition in their own gender,” he said. The absence of such legislation means trans people cannot have their birth certificate reissued to indicate their true gender.
Ms Burton said her legal section had received guidance from the Attorney General’s office in the past week.
Delegates voiced concerns that the legislation may include a compulsory medical examination before trans people could access legal recognition and that married trans people would have to divorce their spouse before accessing recognition. This is due to the constitutional protection of marriage.
Asked about the question of “forced divorce”, Ms Burton said the Attorney General’s report “deals specifically with that issue and of course for the groups it is an issue, but the Irish Constitution and its position on marriage is a matter of fact”.
Ms Burton faced protest from eight members of the audience who held up placards, with “Shame on you Minister Burton”, “Same Old Story” “Not Good Enough” and “15 years and still waiting” as she finished speaking.
Broden Giamrone, director of Transgender Equality Network Ireland, said legislation was needed that respected the community and did not pathologise trans people or tear their families apart.
Senator Katherine Zappone said if Ireland introduced a legislation incorporating a forced divorce clause, “requiring an individual to choose between their family and their identity we will inevitably see more legal challenges, costing more money to the State”.

Molecular milestone: scientists unravel the human genome

      

The 46 human chromosomes, where DNA resides and does its work. Each chromosome contains genes, but genes comprise only 2 percent of DNA. 

In a milestone for the understanding of human genetics, scientists just announced the results of five years of work in unraveling the secrets of how the genome operates.
The ENCODE project, as it is known, dispensed with the idea that our DNA is largely “junk,” repeating sequences with no function, finding instead that at least 80 percent of the genome is important.
The new findings are the latest in a series of increasingly deep looks at the human genome . Here are some of the major milestones scientists have passed along the way.
1. An understanding of heredity, 1866
The realization that traits and certain diseases can be passed from parent to offspring stretches back at least to the ancient Greeks, well before any genome was actually decoded. The Greek physician Hippocrates theorized that “seeds” from different parts of the body were transmitted to newly conceived embryos, a theory known as pangenesis. Charles Darwin would later espouse similar ideas.
What exactly these “seeds” might be was destined to remain a mystery for centuries. But the first person to put heredity to the test was Gregor Mendel, who systematically tracked dominant and recessive traits in his famous pea plants. Mendel published his work on the statistics of genetic dominance in 1866 to little notice. [Genetics by the Numbers: 10 Tantalizing Tales ]
2. Chromosomes come to light, 1902
But the painstaking work of cross-breeding pea plants wouldn’t languish for long. In 1869, Swiss physician Johannes Friedrich Miescher became the first scientist to isolate nucleic acids, the active ingredient of DNA. Over the next several decades, scientists peering deeper into the cell discovered mitosis and meiosis, the two types of cell division, and chromosomes , the long strands of DNA and protein in cell nuclei.
In 1903, early geneticist Walter Sutton put two and two together, discovering through his work on grasshopper chromosomes that these mysterious filaments occur in pairs and separate during meiosis, providing a vehicle for mom and dad to pass on their genetic material.
“I may finally call attention to the probability that the associations of paternal and maternal chromosomes in pairs and their subsequent separation … may constitute the physical basis of the Mendelian law of heredity,” Sutton wrote in the journal The Biological Bulletin in 1902. He followed up with a more comprehensive paper, “The Chromosomes in Heredity ” in 1903. (German biologist Theodor Boveri came to similar conclusions about chromosomes at the same time Sutton was working on his chromosome discovery.)
3. What genes do, 1941
With the link between chromosomes and heredity confirmed, geneticists delved deeper into the mysteries of the genome. In 1941, geneticists Edward Tatum and George Beadle published their work revealing that genes code for proteins , explaining for the first time how genes direct metabolism in cells. Tatum and Beadle would share half of the 1958 Nobel Prize in Physiology or Medicine for their discovery, which they made by mutating bread mold with X-rays.
4. DNA structure decoded, 1953
Now scientists knew that DNA was the molecule responsible for carrying genetic information. But how? And what did this molecule look like?
The pieces of the puzzle were beginning to come together throughout the 1940s. In 1950, biochemist Erwin Chargaff figured out that the nucleotides, or building blocks, of DNA occur in specific patterns. These nucleotides are represented by four letters (A, T, G and C), and Chargaff was the first to discover that no matter the species, A and T always appeared in equal measures, as did G and C.
This discovery would be crucial to James Watson and Francis Crick, the scientists who would describe the structure of DNA for the first time in 1953. Combining Chargaff’s work with studies by Maurice Wilkins and Rosalind Franklin and other scientists, the pair worked out the iconic double helix shape of DNA, a discovery Crick reportedly called “the secret of life.”
5. Human Genome catalogued, 2001
With DNA becoming an increasingly open book, scientists began to tackle genomics, the study of the complete genetic library of organisms. In 1977, researchers sequenced a complete genome for the first time, starting with a rotund little bacteriophage known as Phi X 174. By 1990, science was ready to start something much bigger: a complete cataloguing of the human genome. [Animal Code: Our Favorite Genomes ]
The result was the Human Genome Project, a 13-year international effort that resulted in the complete sequencing of the human genome in 2001. (More detailed analyses of the initial sequence continued after the release of this first draft.) The project revealed that humans have about 23,000 protein-coding genes, a mere 1.5 percent of the genome. The rest is made up of what has been called “junk DNA ,” including fragments of DNA that don’t code for any proteins and chunks of genes that regulate other portions of the genome.
6. Junk DNA de-junked (2012)
Now, the ENCODE project has looked deeper into this “junk DNA” than ever before. And junk it is not: According to more than 30 research papers published today (Sept. 5) in a number of journals including Science and Nature, at least 80 percent of the genome is biologically active, with much non-protein-coding DNA regulating nearby genes in a complex dance of influence. [Mysteries of Human Evolution ]
The findings reveal that the genetic basis of many diseases may not be in protein-coding genes at all, but in their regulatory neighbors . For example, genetic variants related to metabolic diseases pop up in genetic regions that activated only in liver cells. Likewise, regions activated in immune cells hold variants that have been associated with autoimmune disorders such as lupus.
“These breakthrough studies provide the first extensive maps of the DNA switches that control human genes,” study researcher John Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, said in a statement. “This information is vital to understanding how the body makes different kinds of cells, and how normal gene circuitry gets rewired in disease. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology.”