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Monday, June 27, 2016

Donie's Ireland daily news BLOG

HSE paying out €70k each day on private taxis

CAB COMPANIES PAID €73M IN THREE YEARS FOR TRANSPORTING PATIENTS

    

THE HSE SPENDS OVER €70,000 A DAY ON TAXIS – WITH ONE FIRM LAST YEAR RECEIVING ALMOST €1M.

Latest figures show total spend in the past three years has reached some €73m.
Documents obtained by the Sunday Independent show that the agency – which is under unprecedented financial pressure – is now one of the highest users of taxis in western Europe.
The revelation comes just three weeks after an additional €500m was agreed as the latest “special payment” to keep the country’s health services afloat.
And earlier this year it emerged we proportionately spend more on health than any other OECD country – fuelling ongoing speculation the service is not delivering on a value-for-money basis.
Now these latest figures – arising from a Freedom of Information request – show that outlay on taxis continues to escalate. It will renew speculation that there should be more cost-effective methods of transporting patients – and items such as blood specimens – for example, by expanding the ambulance service.
The cost is for transferring patients by private taxi when they are too ill, frail, or unable to travel unaccompanied, to and from appointments.
Figures reveal two taxi companies in Dublin netted almost €1m each over a 12-month period as a result of payments by the HSE.
A third firm in the capital earned over €600,000 – while another taxi company was paid €550,000. A number of taxi firms around the country were also high earners.
Over the course of a year, a firm in Cork earned €755,000 from the health service – and six other taxi companies in the area had earnings ranging from €200,000 to €390,000.
A trawl through the records reveals the biggest earner in the Limerick region received just under €435,000.
Four other taxi, minibus, and hackney firms in the area earned amounts ranging from €150,000 to €214,000 in the space of a year.
Stephen McMahon, of the Irish Patients’ Association, said while transportation should be made available for vulnerable patients, the HSE must ensure they are getting “value for money”.
“Many patients struggle to get from their home to a hospital so we must provide a service for them to do that.
“We don’t know if we’re getting value for money. Are these patients being charged premium rates?
“Do the drivers have experience in basic first-aid? The HSE should think outside the box and consider having their own transportation system attached to the ambulance service.”
Fianna Fail health spokesman Billy Kelleher said it should be acknowledged that “tying up high-end emergency care vehicles and ambulances for transferring patients” is not an option.
“But equally there’s an obligation on the HSE to ensure that they are getting the best value for the taxpayer. Getting value for money should be a key priority. There should be regular audits carried out, and there should be very clear, efficient, and effective tendering, in place as well.”
In a statement, the HSE said the figures provided only include the cost of hiring taxis that comes strictly within its legal ambit. Further expenditure on taxis is incurred by other agencies linked to the overall health service.
Specific data which would show the cost of transporting patients to and from acute hospitals is not available, the statement added.
Mary Tierney of Patient Focus, said ideally all drivers should be capable of basic first aid, which they could use if needed in an emergency situation.

Ireland will resist EU pressure to cut milk output, says Minister Creed

‘FINGER-POINTING AT IRELAND’ UNJUSTIFIED, SAYS MICHAEL CREED AHEAD OF EU MEETING

   
Minister for Agriculture Michael Creed with Enda Kenny.
Minister for Agriculture Michael Creed said Ireland would resist mounting EU pressure to scale back its milk production at this week’s Farm Council meeting in Brussels. The Republic has been singled out as one of the chief drivers of overproduction in Europe, which is now blamed for the current turmoil in dairy markets.
However, Mr Creed said the “finger-pointing at Ireland” was entirely unjustified given the country accounted for 4 per cent of production in Europe and 1% globally.
The latest statistics show the industry here increased output by 18.5% to 6.5 billion litres in the first 12 months since the ending of milk quotas in April last year.
Germany and France, Europe’s two largest producers, recorded more modest output increases of 3.7% and 1.3%, but their production footprints, at 31 billion litres and 25 billion litres respectively, dwarf Ireland’s output.
Compulsory cuts
The Government has resisted restricting supply fearing Ireland, so long the under-achiever in the global milk market, would cede ground to rivals.
Mr Creed said that with the exception of the one dairy lobby group, the Irish Creamery Milk Suppliers’ Association (ICMSA), there was no appetite in Ireland to go down the route of voluntary or compulsory cuts in production. Germany, France and Poland are expected to propose new measures, including supply controls, at this week’s Farm Council meeting aimed at rebalancing the market, amid a near 40% drop in global milk prices since 2014.
The three countries agreed a joint position at a crisis meeting in Warsaw earlier this month and are likely to call on the European Commission to fund voluntary supply cuts at local and national levels.
Income support
Two recent Global Dairy Trade auctions posted modest price increases, prompting suggestions the market may be finally bottoming out, the latest auction in mid-June recorded no change in price. Despite the introduction of several income support measures, several large Irish processors have been accused of short-changing farmers on price.
A recent survey by the Dutch Dairy Board found Irish dairy processors,Glanbia, Dairygold and Kerry, were paying the lowest prices for milk in Europe.

Some 30,000 applicants scramble for €9 an hour Cival Service office jobs

    

ALMOST 30,000 PEOPLE HAVE APPLIED FOR THE MOST BASIC CLERICAL JOB IN THE CIVIL SERVICE WHERE PAY HAS PLUMMETED TO €9 AN HOUR.

Almost 30,000 people – including thousands of third-level graduates – have applied for the most basic clerical job in the civil service where pay has plummeted to €9 an hour.
Many workers are still scrambling for “a permanent, pensionable state job with a family friendly working environment”, according to recruitment experts.
A clerical officer recruitment drive two years ago attracted 28,500 hopefuls.
The avalanche of applications to become part of the public service was the largest since 1993 when there was a recruitment drive at the tail-end of the last major downturn.
But this time round, when applications closed on June 17, an unprecedented 29,811 had applied.
Clerical officers perform administrative and clerical duties, and are expected to complete tasks such as typing, data input computer work and filing.
Despite the unprecedented number of applicants, it is understood the Public Appointments Service is looking to fill fewer than 1,000 positions countrywide. It is also believed the majority of the vacancies are based in Dublin.
During the Celtic Tiger years, similar front-line positions were difficult to fill, and the majority of successful candidates had left education right after they completed the Leaving Certificate.
Appointments were made without the requirement of a formal interview.
Given the high number of applications following this latest recruitment drive, it could be some months before the successful candidates begin employment.
Speaking today, Michael McDonagh, director of Hays Recruitment Agency in Dublin, says workers are still “hugely attracted” to a guaranteed income provided in the semi-state and state sector.
“All the pain endured since the economic crash has made many people really attracted by the idea of what is described as the permanent, pensionable job,” he added.

Talking therapy is on rise? but who are we talking to?

THERE IS A BEWILDERING CHOICE OF THERAPISTS AND THERAPIES OUT THERE – BUT LITTLE REGULATION

     
There is little regulation of the therapy market.

TALK THERAPY MAY BE ON THE RISE IN IRELAND, BUT CLIENTS STILL AREN’T ASKING THEIR THERAPISTS ABOUT THEIR QUALIFICATIONS AND ACCREDITATIONS.

While Irish people may euphemistically concede that they are “talking to someone”, they often don’t know who exactly that person is, or what the letters after their name mean.
There is a bewildering choice of therapists and therapies available in Ireland, coupled with a woeful lack of consumer information. Furthermore, psychotherapists and counsellors are not currently regulated under the Health and Social Care Professionals Act 2005.
“The persistent lack of regulation in psychotherapy is profoundly concerning,” says cognitive scientist and philosopher of medicine Dr Charlotte Blease.
“There is still no statutory regulation for therapists in Ireland (though there are moves in this direction with CORU). And unlike medicine, it is not possible to become a licensed psychotherapist.
“Anyone can stick a plaque on their door, set up an internet site, dub themselves a ‘therapist’ and start charging by the hour. I also imagine that many of these people are falsely calling themselves ‘Dr’ or even ‘Professor’,” she adds.
Counselling and psychotherapy are self-regulated industries in Ireland. Just as psychology is accredited by associations such as the Psychological Society of Ireland (PSI), counselling and psychotherapy are accredited by bodies such as the Irish Association for Counselling and Psychotherapy (IACP); the Irish Association of Humanistic & Integrative Psychotherapy (IAHIP); and the Association of Psychoanalysis and Psychotherapy in Ireland (APPI).
These bodies have stringent standards of excellence and therapists are required to partake in a mandatory number of client contact-work hours (450 hours for prospective IACP members) after successful completion of core work.
“Psychotherapists who are members of bodies such as the IACP, and similar organisations, must adhere to strict ethical codes of conduct to respect patient autonomy, client confidentiality, and to conduct themselves in a professional manner,” says Dr Blease.
Non-membership doesn’t disqualify therapists from practicing though, as psychotherapist and Love Rewired author David Kavanagh explains.
“People can do a course that is accredited to a proper organisation but then not necessarily go off and get the proper registration hours that they need. If they don’t get the registration hours that they need, then they are not officially registered.”
Kavanagh’s clients often ask him to explain the difference between a counsellor and a psychotherapist.
“I always answer ‘about seven years’ training’. I have a degree, a diploma, three years post-grad and then two years to get registration. It was a nine-year educational process for me to become a psychotherapist with the Family Therapy Association of Ireland.
“Yet I could become a counsellor in six months after doing my Leaving Cert. Or I could do a six- week course in counselling online, get a certificate from America, put myself forward and nobody is legislating against me.”
Dublin-based psychotherapist Liam Plant, who is accredited with three bodies, both here and in the UK, believes that therapists are ethically obliged to tell clients if they are still in the process of becoming accredited. He also offers a list of ‘questions to ask your therapist’ on his website.
“There was a proliferation in the noughties of private colleges offering courses that maybe didn’t pay sufficient attention to the highest standards of practice,” says Plant. “I personally think the minimum level of education should be a Masters.”
Thankfully, the Irish industry is slowly moving in this direction. The IACP is increasing the minimum educational requirement for Counselling & Psychotherapy (for the purpose of accreditation) to Degree Level 8 on the National Framework of Qualifications from September 2018.
This will significantly up the ante of an already challenging programme, says copywriter Laura-Kelly Walsh, who is currently studying part-time for an IACP-recognised diploma in psychotherapy over two years. Her studies include 450 hours of training, 50 hours of personal therapy and 150 hours of supervised practice.
“I realised how important it is to do an IACP or IAHIP accredited course after researching the courses available in Ireland,” she explains. “Also, given the nature of the profession, an online course was out of the question.”
Psychotherapist Barbara Foley became IACP-accredited a year ago. She originally trained as a nurse before working in clinical research for 12 years. She started a degree in psychotherapy six years ago, practiced for two years before becoming fully accredited and is currently studying for a two-year post-grad in adolescent psychotherapy.
“My concern is the rise of online courses in things like CBT [cognitive behavioural therapy], NLP [Neuro-linguistic programming] and mindfulness,” she says. “I’m not aware of the accreditation around them and I just wonder how vigilant people are about researching the regulatory process.”
Dr Blease has similar reservations.
“A friend of mine suggested going to ‘mindfulness classes’. I went along with her twice, purely out of curiosity for the standard of care. I was appalled. I have no idea what kind of training he received and I witnessed this ‘therapist’ tell one patient (who had made it known that he was grieving) that, ‘cancer is caused by the food that we eat’.”
“The problem with Ireland is that people don’t ask enough,” adds Kavanagh. “They don’t say ‘tell me about your qualifications and expertise’. They don’t ask ‘where did you train, who did you register with, are you insured?'”
Foley agrees. She says that while GPs will only refer patients to registered psychotherapists, clients are considerably less ¬attentive about looking for ¬accreditations. One way to navigate this is to find a reputable centre. MyMind, a not-for-profit provider of mental health care services, requires all therapists to be practicing under a recognised accreditation body and to be undergoing regular supervision.
“Finding a therapist in your area can be done through consulting the directories of professional bodies,” explains MyMind communications officer Carmel Bryce. “It can also be helpful to have a recommendation from a trusted source, such as a GP or friend.”
Patients should also be educated about the therapeutic process and the possible risks, says Dr Blease.
“They deserve to be made known about evidence which shows that some versions of therapy will be more suitable for their problems than other kinds of therapy.
“They also deserve to be told that therapy may carry risks: around 10pc of patients experience worsening of symptoms as a result of long-term therapy. Honest and competent therapists – therapists who are working within the sphere of evidence-based practice – will make patients aware of these facts.
“Just because psychotherapy involves talking does not mean it is harmless.”

In vitro fertilisation may save coral reef decline

    

MARINE BIOLOGISTS AT THE CALIFORNIA ACADEMY OF SCIENCES HAVE JOINED A NEW INTERNATIONAL EFFORT TO RESCUE ENDANGERED CORAL REEFS FROM THE CONSEQUENCES OF WIDESPREAD HUMAN DESTRUCTION AND A WARMING CLIMATE.

Teams of research divers from the academy will set off this summer on expeditions to the Caribbean and Mexico, where they will seed two of the region’s major reefs with millions of coral larvae born from the organisms’ sperm and egg cells.
As colorful as flower bouquets, corals are actually colonies of tiny animals that build their limestone homes from the sea, and derive their colors from the algae that live inside them. Their lives are increasingly threatened by global plagues like expanding human development, ocean pollution, and the twin signals of global climate change: rising temperatures and increasing ocean acidification.
A call to action from three Pacific island nations whose coral reefs are in the crosshairs of the largest and longest-lasting coral bleaching event in recorded history will be presented Friday at the conclusion of the International Coral Reef Symposium in Honolulu. Heads of state from Palau, Micronesia and the Marshall Islands attended the conference and provided a plan to help save their ailing coral reefs, which are major contributors to their local economies and the daily sustenance of their people. The call to action, signed by the three presidents, asked for better collaboration between the scientific community and local governments, saying there needs to be more funding and a strengthened commitment to protecting the reefs.
Recent record-shattering El Niños have raised Pacific Ocean temperatures and caused a new worldwide episode of coral bleaching that is turning the organisms dead white. The scourge began in 2014, according to the National Oceanic and Atmospheric Administration, and is already the worst and longest bleaching episode in history.
Bart Shepherd, the director of the academy’s Steinhart Aquarium, and Luiz Rocha, the curator of ichthyology, will lead about 20 divers on a new experiment in coral reproduction.
“If it’s successful,” Shepherd said, “it opens the possibility for widespread application on coral reefs everywhere.”
Shepherd’s group has joined with leaders of an international research and conservation group called Secore International — Sexual Coral Reproduction — whose founder and president, Dirk Petersen, led the original research into a unique method of in vitro fertilization of coral organisms.
Five years ago, Petersen and researchers diving at the Caribbean Marine Biological Institute in Curacao, collected coral sperm and egg cells in the water while the corals were spawning, and reared the coral larvae in the laboratory. When they matured, the researchers transplanted the coral larvae onto small, fist-size tiles that the divers then transplanted to the degraded reef by the thousands.
The experiment was successful and within two years a high proportion of new corals were flourishing and growing, Petersen and his colleagues reported in the journal Global Ecology and Conservation.
“This is now actually a five-year plan, and eventually it could become a global restoration project for corals everywhere,” Petersen said during a recent visit to San Francisco, where he and Shepherd completed working on details of the academy team’s role this summer.
The expedition is scheduled for August because the corals spawn only about once a year, releasing their sex cells into the water by the millions, Shepherd explained. The event, he said, occurs only in August at night and only within a few days after a full moon.
It’s during those fleeting nights of spawning action that Shepherd and his colleagues from the academy will be diving to collect the coral gametes. Then, after they have become larvae in the Caribbean institute’s lab, the divers will return to seed the nearby reef with the fresh infant corals.
The researchers’ first two targets will be on the degraded reef at the institute’s field station in Curacao, and then on the Yucatan Peninsula, where the famed Great Maya Reef stretches more than 620 miles south to the coast of Belize.
The academy’s effort at coral midwifery is part of a $10 million commitment the institution has made specifically to research and restoration efforts on the world’s endangered reefs.
“We’re planning 20 new expeditions over the next five years to regions where coral reefs are threatened,” said Jonathan Foley, the academy’s executive director. “And our people will be putting boots on the ground for a rescue experiment that’s unique — not just for proving out a new technique to restore coral reefs, but for making the technique better.”     

Saturday, June 25, 2016

Donie's Ireland daily news BLOG.

IDA set to negotiate with UK companies to relocate to Ireland after Brexit vote

THE AGENCY IS TO BEGIN NEGOTIATIONS WITH COMPANIES LOCATED IN UK THAT MAY WANT TO RELOCATE TO IRELAND.

   

MARTIN SHANAHAN (picture left), THE CHIEF EXECUTIVE OF IDA IRELAND, SAYS THE STATE AGENCY WILL SOON BEGIN NEGOTIATIONS WITH BANKS AND OTHER COMPANIES LOCATED IN THE UK THAT MAY WANT TO RELOCATE TO IRELAND FOLLOWING THE BREXIT VOTE.

Martin Shanahan, the chief executive of IDA Ireland, says the State agency will soon begin negotiations with banks and other companies located in the UK that may want to relocate to Ireland following the Brexit vote.
Mr Shanahan stressed his first preference was for Britain to remain within the European Union (EU), but he said the IDA has “done its homework” on how to maximise foreign investment for Ireland now that the UK has voted to leave.
“We have been in discussion with potential clients [who may choose to relocate to Ireland from the UK] for months. They approached us,” said Mr Shanahan. “We have a good view on the potential for Ireland.
He said discussions with potential foreign investors could begin as soon as “next week, or the week after”.
IDA’s existing 1,200 client companies are “still digesting the news”, he said. Mr Shanahan yesterday wrote to the 1,200 to say Ireland remains committed to the EU and is effectively still open for business.
He said Ireland’s “stability” would be an attractive feature when attracting new investment in the midst of the uncertainty created for the UK by the vote. Mr Shanahan also agreed that financial services and technology were two sectors where Ireland would be particularly well placed to pick up fresh foreign investment that might otherwise locate in the UK.
“But we intend to push for investment right across the portfolio, including life sciences and engineering,” he said. “Our mandate prior to Brexit was to maximise investment for Ireland, and nothing has changed in that regard.”

TERMS OF EXIT?

Fergal O’Brien, chief economist at the employers’ lobby Ibec, said the UK is now likely to “become more aggressive” in securing foreign investment to protect its economy, which could increase competition faced by the IDA.
He said a lot depends on the terms of the exit deal given to the UK, including its level of access to the EU’s internal market: “It is in Ireland’s interests to get as much stability as possible for the UK.”
Mr O’Brien suggested that while other EU states might want to impose tough measures on the UK to discourage other countries from exiting, Ireland “needs to establish at EU level that we have skin in the game” and push for leniency.
Enterprise Ireland, meanwhile, warned against the effects of exchange rate volatility for Irish exporters into the UK. It said it would also support Irish exporters to devise medium-term diversification plans.
“In addition to our team in the UK, we have put in place a dedicated email address, phone-line and team for Enterprise Ireland clients to respond to their immediate concerns and issues,” said the agency.

Ryanair and Aer Lingus could be hit by fall in passengers

INTERNATIONAL AIR TRANSPORT ASSOCIATION SAYS WEAKER STERLING MAY CUT NUMBER OF UK TRAVELLERS

   

IAG SAID IT NO LONGER EXPECTS TO GENERATE AN ABSOLUTE OPERATING PROFIT INCREASE SIMILAR TO 2015.

Ryanair and Aer Lingus parent, International Airlines’ Group (IAG), could be hit by a fall in UK passenger numbers following the Brexit vote, according to a leading industry body.
The International Air Transport Association (IATA) predicts that a weakened sterling and shrinking economy could cut UK airline passenger numbers, which hit 250 million last year, by 3 to 5% by 2020.
A report the association published yesterday shows that Ryanair and IAG, owner of Aer Lingus, are amongst the airlines that are most exposed to a fall in air travel.
The UK is one of Ryanair’s biggest markets, accounting for more than 30 million of the 100-plus million passengers that it flies every year.
This gave it a large share of the 117 million people that flew between the UK and the rest of the EU last year. It also employs 4,000 people there.
IAG’s other airlines include British Airways, which carried more than 43 million people last year. The group warned in a statement following the vote that it does not expect this year’s growth in operating profits to match that of 2015.
Ryanair’s chief marketing officer, Kenny Jacobs, said that the Irish company would campaign to have the UK remains in the EU’s Open Skies regime, which allows airlines to fly freely between member states.
However, he indicated that Ryanair is more likely to spend money on countries within the EU, such as the Republic, Germany, Spain and Italy. “It’s going to mean that when we are looking at investing, we will look outside the UK,” he said.
The vote sent travel stocks tumbling. IAG fell 22.54% to 409 pence sterling in London. Ryanair shares were down 11.77% at €12.07 in Dublin.
Shaun Quinn, chief executive of State body, Fáilte Ireland, responsible for promoting tourism to the Republic, said it was too early to speculate on the likely impact of the vote on the industry.
“Fáilte Ireland will be monitoring any short term impacts of a devalued sterling on tourist numbers to Ireland and working with businesses in the sector to develop strategies to address any arising competitiveness challenges,” he said.
The Irish Hotels Federation warned that there was a risk a risk that economic uncertainty and a weaker sterling would hit visitor numbers from the UK.
Republic attracts three million tourists from Britain every year. The hospitality industry fears that this number could decline as the Brexit fallout continues.

Sligo seeking funding as European Volunteer Capital

Sligo, Ireland, Finds Working Capital in Its Couch Cushions     

CONCERN HAS BEEN EXPRESSED THAT NO FUNDING HAS YET BEEN ARRANGED FOR SLIGO’S DESIGNATION AS EUROPEAN VOLUNTEERING CAPITAL 2017.

The manager of Sligo Volunteer Centre Ciara Herity told councillors last week that while the supports from the Municipality were in place, no concrete funding was secured.
“We are the first non-country capital winner. It’s very exciting, for Sligo and for Ireland. The uniqueness of Sligo winning is that we are a small rural county on the periphery of Europe. It’s a privilege to have it,” she said.
Cathaoirleach of the County Council Cllr Rosaleen O’Grady said she was “concerned that they’ve no funding” but added that they had “the right woman in Marian Harkin in Europe” to help them source funding.
The MEP is Patron of Sligo Volunteer Centre and attended the presentation in person last week.
Sligo beat seven other cities in the running for the 2017 designation and previous winners include London, Lisbon and Barcelona.
Sligo Volunteer Centre celebrates its 10 year anniversary in 2017 and the designation will give due recognition to that.
M/s Herity said the designation would bring more European visitors here along with an economic boost to the town and county.
It’s hoped Sligo will host some national events: Volunteer Ireland, Special Olympics, Foroige and the Irish Girl Guides have been approached about hosting events here next year.
Cllr Sean MacManus said it was “a fantastic achievement for a small county on the periphery of Europe”. He said it was going to be difficult to match London and Lisbon “especially in view of the fact that we’ve no funding.”
“Even given Sligo County Council’s straitened financial situation to include some forming of funding to back them up,” he said.
Cllr Sinead Maguire also congratulated Sligo Volunteer Centre and said “It does reflect the spirit of volunteering that we have here in Sligo. We’re worthy winners.”
Council Chief Executive Ciarán Hayes is now tasked with designing a programme of events, actively pursuing sponsorship and raising awareness.

Marked reduction in PSA testing

 Pictured left to right at the John Fitzpatrick Irish Prostate Cancer Conference in Dublin were: Mr Killian Walsh, Prof Michael Blute, Mr Peter Ryan and Mr Andrew Fitzpatrick   

A US TASK FORCE RECOMMENDATION AGAINST PSA-BASED SCREENING HAD A MAJOR EFFECT, GARY CULLITON HEARD AT THE JOHN FITZPATRICK IRISH PROSTATE CANCER CONFERENCE. SINCE THIS POLICY DECISION WAS MADE, THERE HAS BEEN A CONSIDERABLE IMPACT ON RATES OF DETECTION

Policy decisions are rapidly influencing primary care practice in the US. There has been a decrease in prostate-specific antigen (PSA) screening, and the urology response has been an increase in the use of active surveillance in men with low-risk disease. Recent years have also seen the advent of surgical cohorts with more intermediate and high-risk disease.
A recommendation against PSA screening may be leading to later stage disease at diagnosis, a meeting in Dublin has heard.
There has been a shift toward more advanced disease at diagnosis, and decreased use of PSA-based screening may worsen this trend.
The rapid decrease in PSA use was concerning, said Prof Michael Blute, Chief of Urology at Boston’s Massachusetts General Hospital and Professor of Surgery at Harvard. This would continue until there was a change at policy level, he said, in a talk on policy decisions and the changing face of prostate cancer at the John Fitzpatrick Irish Prostate Cancer Conference in Dublin recently. His talk dealt in particular with diagnosis and management in the US.
More surgical patients are seen with advanced or adverse pathology. “My hope is that smarter prostate cancer screening methods will be introduced,” said Prof Blute. One of his concerns centres on “reaching primary care practices.”
In 2012, the US Preventive Services Task Force (USPSTF) recommended against PSA-based screening for prostate cancer. There was moderate or high certainty that the service had no net benefit or that the harms outweighed the benefits, said the Task Force, which discouraged use of the service.
Since this policy decision was made, there has been a major impact on rates of detection. Urologists order between 7 and 10 per cent of the PSA tests in the country. The vast majority of PSA tests are ordered by primary care practices.
Dramatic reduction
A dramatic reduction was seen in the utilisation of PSA testing in primary care practices (Ahmedin Jemal, 2015). There were then conflicting results from the PLCO and ERSPC trials and the case against screening appeared to strengthen.
Following the 2012 USPSTF recommendation, there has been a 20 per cent reduction in the use of PSA testing in the United States and rates would continue to fall, said Prof Blute. “The argument about PSA screening became an ‘all or none’ debate. The ‘none’ side won out. This is having a significant impact for men diagnosed with prostate cancer at our practice.”
Overall incidence among the cohort of men aged 50 and older in the US dropped off in 2012. However, the presentation stage — for localised disease or metastatic disease — has not changed; it lags behind. For the first time in two decades, the incidence of metastatic disease among men aged 75 years or older is starting to creep up.
“My fear is that primary care practices are not listening to American Urological Association (AUA) guidelines. They are not listening to National Comprehensive Cancer Network (NCCN) guidelines. They are listening to the USPSTF,” Prof Blute said.
Since the 2012 USPSTF recommendation, there has been a 28 per cent reduction in the diagnosis of prostate cancer in the US (Barocas DA, J Urol, 2015). Equal reductions have been seen in the diagnosis of men with low-, intermediate- and high-risk cancers. “This is an extremely rapid change and it is a real concern for men with intermediate- or high-risk disease who will experience delay in diagnosis,” said Prof Blute. Delayed diagnoses would be a feature and an increase in the incidence of men with metastatic disease at diagnosis was sure to follow, he said.
The recommendation has been associated with decreased PSA screening in all age groups, decreased rates of prostate biopsies and decreased incidence of prostate cancer. There has been no change in the distribution of low-, intermediate- and high-grade disease. There have been no changes thus far among men aged between 50 and 74. Increases in men presenting with metastatic disease 75 years and older are now seen (Ahmedin Jemal, 2015). Men in the 50-to-70 years bracket would have a similar response if there was continued reduction in the utilisation of PSA, Prof Blute predicted. An increase in absolute and relative amounts of late stage prostate cancer would be seen, he predicted.
Increased numbers.
A hugely increased number of men with low-risk disease were identified following the introduction of PSA testing.
Seventy-to-80 per cent of the diagnoses were low-risk. Now, almost 40 per cent of men with newly diagnosed prostate cancer are placed — appropriately — in active surveillance protocols (National Cancer Database, 2004 to 2013).
Between 2004 and 2012, intermediate- and high-risk men were increasingly seen among surgical cohorts. Low-risk men may not benefit from aggressive therapy, but because of progression or repeat sampling biopsies that reveal higher grade disease in 20 per cent of cases, men may be upstaged to intermediate risk disease.
Data covering private practice urology in the US showed a drastic reduction in use of ADT monotherapy for patients with the highest risk on Cancer of the Prostate Risk Assessment (CAPRA) score after 2004 (Cooperberg, JAMA, 2009). Use of radical prostatectomy more than doubled. There was a continued reduction in primary androgen deprivation therapy as monotherapy among men aged 75 and older. There was also an increase in the utilisation of more aggressive therapy for patients who had higher-risk disease.
Pathologically, there has been a reverse stage shift: operations have been performed on more men with higher-risk disease. From 2000 to 2010, the number of men who underwent radical prostatectomies for low-risk disease, dropped drastically — from 50 to 30 per cent (Silberstein, Cancer, 2011). By contrast, the number of men with high- and intermediate-risk disease increased. More and more men with adverse pathology results would be seen following radical prostatectomy, said Prof Blute.
The number of men operated on with organ-confined disease was falling, but more men with extra-prostatic disease were seen.
However, there was a reduction in operations on men with primary pathologic Gleason Score Six disease.
Low-risk tumours are more frequently treated with active surveillance in the US, while high-risk tumours are more frequently treated with surgery. The recommendation against PSA screening is leading to a reverse Stage migration.
Prof Blute spoke about the role of MRI in surgical management of prostate cancer. There would be an increased tendency to operate on more aggressive tumours. Some cancer cells may be left behind (increased positive surgical margin rates) and there would probably be less favourable cancer control outcomes locally — particularly where surgery was used as single-modality treatment. Use of adjuvant therapies and pelvic lymph node dissection would also increasingly be considered.
Men in the high-risk cate-gory are a heterogenous group. Those with high-risk disease who have a single adverse variable do better than men with multiple adverse variables. In terms of management, surgery is included in guidelines by the National Comprehensive Cancer Network (NCCN) for cases of resectable disease, but unlike breast or colorectal cancer, algorithm surgery has not been tested in a multimodal fashion with radiation and hormone therapy.
Where surgery is used for initial management in high-risk disease, overall 10-year cancer-specific survival is 80-to-90 per cent (Stewart, 2015). Many men do well, where their high-risk disease is managed using surgery. Fifteen-year outcomes were published on a series of men with clinical T3 disease who had operations. The complication rate among these men — who underwent wide local excision of their cancers — was studied. They had good outcomes — equivalent to T2 disease. In terms of urinary control, 80 per cent of these men were completely dry (Ward, 2005, BJUI).
MRI is used to stage these patients prior to surgery. The same techniques used in low-risk men cannot be used to operate on men with high-risk disease. Extended pelvic lymph node dissections are recommended as the node positive rate for high risk disease will be 10 to 15 per cent. There would be risk associated with dividing the lateral pelvic fascia and releasing the neurovascular bundle and not achieving negative surgical margins. Therefore, an extrafascial approach is favoured for men with high-risk disease.
An objective was to elevate the rectoprostatic fascia so there was a wide surgical margin in the patient, said Prof Blute.
Using wide local excision surgery as an initial treatment among 1,800 men with high risk disease, 57 per cent of men ultimately had pathologically organ-confined disease and did well (Boorijian, J Urol, 2008). Ten-year local recurrence-free survival was 90 per cent. Local recurrence-free survival in these men (who often had at least T3 disease) was equivalent to that in men with T2 disease.
Profiling
Increasingly, a biomarker has been used. The Decipher test is a genomic classifier. Some 545 Mayo Clinic patients with high-risk disease were selected following radical prostatectomies (Erho, Crisan, PLOS One, 2013). These men had biochemical recurrence and a test was sought that would predict metastases.
Some 192 cases developed metastases. Transcriptome-wide expression profiling was carried out to identify signalling pathways associated with metastases.
If the Deci¬p¬her score indicated a low risk, only 2.4 per cent of men ultimately demonstr-ated metastases. The genomic classifier was judged to yield independent prognostic information in a multivariable analysis. The Decipher test was found to be the only significant variable for detecting rapid metastases and it performed well, compared to the CAPRA-S and Stephenson nomograms (Klein, Euro Urology 2015).
The Decipher test provided additional stratification in terms of risk (Ashley Ross, Johns Hopkins). Molecular stratification has been needed to classify men with high-risk disease better. There is a concern about additional toxicities in these men (who have undetectable PSA, are responding well to their surgery and have good quality of life).
Multivariable analysis demonstrated that genomic high-risk men, who received ART, had higher metastases-free survival, compared to salvage radiation treatment. An 80 per cent reduction in risk of metastases was demonstrated, among the Decipher high-risk group getting ART — rather than salvage — therapy.
Metastates
This would hopefully inform the debate about the timing of radiation treatment in the post-op setting, said Prof Blute. The genomic classifier would be very helpful in men who had high risk disease. Data showed that significant numbers of men with adverse pathologies did not develop clinical metastases. They do well and do not need adjuvant therapies.
Introducing a genomic classifier for this group of men would be very valuable in stratifying who needed the therapies and when. In patients with adverse pathology and a low-risk genomic classifier result, a careful eye should be kept on the PSA results, data indicate. More prospective studies were required, said Prof Blute.
In the current era, aggressive treatment of localised prostate cancer was increasingly being reserved for those men who needed it the most, and active surveillance for men with low-risk disease.
In the future, surgical cohorts would be increasingly intermediate- and high-risk patients, and focus must be on managing adverse pathology after surgery to achieve long-term local control of prostate cancer, added Prof Blute.

Crops grown on Mars soil are safe to eat

   

ECOLOGIST WIEGER WAMELINK INSPECTING THE PLANTS GROWN ON SOIL SIMILAR TO THAT ON MARS AT THE WAGENINGEN UNIVERSITY.

Results from trials using soil like that on Mars hold promise for future settlements on planet
Dutch scientists said crops of four vegetables and cereals grown on soil similar to that on Mars have been found safe to eat, amid plans for the first manned mission to the planet.
Abundant harvests of radishes, peas, rye and tomatoes all grown on the soil were found to contain “no dangerous levels” of heavy metals, said the team from Wageningen University on Thursday.
“These remarkable results are very promising,” said senior ecologist Wieger Wamelink. “We can actually eat the radishes, peas, rye and tomatoes, and I am very curious what they will taste like.”
Future Mars settlers will have to take food supplies with them and then plant crops in order to survive.
So using soil developed by Nasa to resemble that of the Red Planet, the university in the Netherlands has been experimenting since 2013 and has managed to raise 10 crops.
There is uncertainty still about their absorbing the high levels of heavy metals such as cadmium, copper and lead present in Mars soil. Further tests are needed on the other six crops, including potatoes, in research being backed by a crowd-funding campaign.
Nasa plans a manned trip to Mars within the next 10 to 15 years or so, and similar projects are being pursued by US billionaire Elon Musk and Dutch company Mars One, tentatively aiming to set up human colonies on the Red Planet.
The Mars One project has backed the Wageningen work and is deciding on the final 40 out of 100 candidates hoping to be its astronauts.
But unlike any Nasa mission, Mars One is a one-way trip: Whoever joins this journey to the foreign world is never, ever coming back to Earth, Fox 5 News reported.
Mars One CEO Bas Landsdorp estimates the project will cost US$7 billion (S$9.5 billion). He plans to pay for it in part by turning the mission into a reality show.
But space expert Neil deGrasse Tyson is sceptical.
“I try not to get in anybody’s way who is dreaming big,” he told Business Insider after Mars One announced the project in February last year. “But I’m sceptical it can be accomplished on the timescale” given.